About 11.30pm, a 16-year-old boy was riding his Kawasaki motorcycle down Marion Street in Bankstown when he crashed with a Toyota Echo at the intersection with Little Street.

Police were immediately called and paramedics treated the boy, but he died at the scene.

Two dead following crashes in Razorback and Bankstown: http://t.co/N7S2Td3ooM #9News pic.twitter.com/3QgDQYm5Tb— Nine News Sydney (@9NewsSyd) May 29, 2015

The 44-year-old male driver of the Echo, and his 30-year-old male passenger, avoided injuries. The driver underwent mandatory blood and urine testing at Bankstown Hospital.

Later in the night in a separate accident, a man believed to be in his 20s died.

About 1.45am, a black Nissan Skyline and a white Toyata sedan collided head on along Mount Hercules Road in Camden.

The passenger of the Skyline died in the smash. The driver, also in his 20s, was taken to Liverpool Hospital with critical injuries.

The driver and passenger of the Toyota, a man and woman believed to be in their 20s, were also taken to Liverpool Hospital. They sustained non-life threatening injuries.

Earlier on Friday, a 70-year-old woman nearly died in a crash in the central NSW town of West Wyalong.

She was behind the wheel of her Toyota sedan when she hit a b-double truck on Newell Highway.

Her car then slammed into a Toyota van being driven be a 30-year-old Griffith man.

She was pinned in the wreckage and had to be released by emergency workers.

She was treated at the scene and taken to West Wyalong Hospital. She was then taken by helicopter to Canberra Hospital in a critical condition.

The male driver of the second car sustained minor injuries and is being treated at Temora Hospital.

The truck driver was not injured and underwent mandatory blood and urine testing at West Wyalong Hospital.

Police say crime scenes have been established at all three sites, and investigations are continuing.

Police are urging anyone with more information about the crashes to contact them via Crime Stoppers on 1800 333 000.